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The Student Center houses the campus bookstore, community lounge, mailboxes, café and Student Government Association office on the first floor. On the second level, Howard Hall, a multi-purpose room, provides gym space as well as seating for 400 people. Next door is the J.W. Upright Success Center, which caters to the study, tutoring and counseling needs of students.

In the main building at 42 and Dodge Streets, the lower level (LL) houses the Professional Development office, Life Support training center, Nurse Aide classroom, Testing Center and skills laboratory for the Radiologic Technology and Medical Imaging programs. The Educational Resource Center (ERC) is also located in the lower level.

On the first floor lobby of the College main building you will find the Student Services Suite. The Admissions, Registrar, Student Financial Services and Facilities offices are housed in this suite. The Student Services Suite provides centralization of student services and information to students and visitors. The first floor also houses classroom 110.

The second floor houses the College Library. Maintaining convenient hours, the Library provides students with knowledgeable staff and resources necessary to complete projects and conduct research.

The second floor also houses classrooms and a science lab for the anatomy, physiology, chemistry and biology classes. Just beyond the science lab is Second Floor South, which houses the Center for Teaching Excellence (CTE) and the skills laboratory for the Physical Therapist Assistant program.

The Center for Teaching Excellence (CTE) was established in 2008 to support teaching and learning at Clarkson College by assisting faculty and academic programs in their continued pursuit of course improvement and student learning. CTE manages and coordinates instructional design, faculty development, online education, testing center, diversity, community service, Service-Learning, accommodations, and institutional effectiveness services for faculty and academic program needs.

The third floor provides the College with a multipurpose area that can quickly be configured as two large rooms or three areas for instruction, activities or workshops. The third floor also houses the College computer lab. Faculty members are also located on the third floor.

Located on the fourth floor are classrooms and the offices for the Director of Radiologic Technology and Medical Imaging and the Technology and Computer Services department. Also housed on the fourth floor is the Nursing Skills Lab and state-of-the-art Simulation Lab.

Clarkson College faculty offices, the Director of Undergraduate Nursing and the Assistant Director of Undergraduate Nursing are located on the fifth floor.

The sixth floor of the College houses the administrative offices of the President, Vice President of Academic Affairs, Vice President of Operations, Dean of Nursing, Director of Graduate Nursing and Doctor of Nursing Practice, Director of Health Care Business, Director of General Education, Fiscal Services, Human Resources, Marketing, Academic Travel Abroad (ATA) and Alumni Relations.

Advanced technology is architecturally designed into the main building of the College, Student Center and Residence Hall including wireless Internet access in each building and the courtyard. The facilities were built to handle current and future computer and technological needs. All main building classrooms are equipped with television monitors as well as numerous types of audio/visual projection equipment. The capability exists to transmit live or taped productions into all classrooms simultaneously. Throughout the College facilities are connections that link users of technology with computers, modems, satellites and the Internet. Education at Clarkson College is truly global.